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nkhani

Zolemba

Melanoma imangokhala ndi 4% yokha ya khansa yapakhungu koma ndi imodzi mwazotupa zowopsa kwambiri. Dacarbazine ndi mankhwala omwe amasankhidwa pochiza khansa yapakhungu ku Brazil kudzera munjira yaboma makamaka chifukwa chotsika mtengo. Komabe, ndi alkylating wothandizila otsika specificity ndi kumapangitsa yankho achire 20% okha milandu. Mankhwala ena omwe amapezeka kuchiza khansa ya pakhungu ndiokwera mtengo, ndipo ma cell am'matumbo nthawi zambiri amayamba kukana mankhwalawa. Kulimbana ndi khansa ya khansa kumafuna mankhwala atsopano, omwe ndi othandiza kupha maselo osagonjetsedwa ndi mankhwala. Zotengera za Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) zikulonjeza othandizira ku antitumor. Phunziroli, tidasanthula mphamvu ya cytotoxic ya 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) pama cell a B16F10 melanoma komanso kulumikizana kwawo molunjika ndi molekyulu ya DNA yomwe imagwiritsa ntchito ma tweezers owoneka. DPBP idawonetsa zotsatira zolonjeza motsutsana ndi ma cell a chotupa ndikukhala ndi index ya 41.94. Komanso, tawonetsa kuthekera kwa DPBP kuyanjana molunjika ndi molekyulu ya DNA. Chowonadi chakuti DPBP imatha kulumikizana ndi DNA mu vitro kumatilola kuganiza kuti kulumikizana koteroko kumathanso kuchitika mu vivo, chifukwa chake, DPBP itha kukhala njira ina yochiritsira odwala omwe ali ndi melanomas osagwira mankhwala. Zotsatira izi zitha kuwongolera pakupanga mankhwala atsopano komanso othandiza.

Zithunzi zojambula

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Chiwerengerochi cha kuchuluka kwa imfa yamaselo yopezedwa ndi gulu la DPBP motsutsana ndi mizere ya melan-A ndi B16F10 m'malo osiyanasiyana. Zosankha zosankha (SI = IC50 melan-A / IC50 B16F10) zinali 41.94.                    

Lofalitsidwa ndi Elsevier BV

Zolemba

Dibenzoylmethane (DBM) ndi gawo laling'ono la licorice komanso analogue ya curcumin ya β-diketone. Kudyetsa 1% DBM muzakudya kwa mbewa za Sencar panthawi yonse yoyambira komanso nthawi yoyambira kuyimitsa zidaletsa kwambiri 7,12-dimethylbenz [a] anthracene (DMBA) -kuwonjezera kuchuluka kwa chotupa cha mammary ndi chotupa cha mammary ndi 97%. Kupitilira mu maphunziro a vivo kuti afotokozere njira zomwe DBM ingaletsere, kudyetsa 1% DBM mu chakudya cha AIN-76A kuti mbewa za Sencar zazing'ono kwa milungu 4-5 zachepetsa kuchepa kwa uterine ndi 43%, kuletsa kuchuluka kwa kuchuluka a mammary gland epithelial cell ndi 53%, uterine epithelium ndi 23%, ndi uterine stroma ndi 77%, pomwe mbewa zidaphedwa gawo loyamba la estrus. Kuphatikiza apo, kudyetsa 1% DBM pazakudya kwa mbewa za Sencar m'masabata awiri m'mbuyomu, mkati ndi sabata limodzi pambuyo pa chithandizo cha DMBA (kulumikizidwa kwa 1 mg DMBA pa mbewa kamodzi pa sabata kwamasabata 5) kudaletsa mapangidwe okwanira a DMBA-DNA adducts mu mammary glands ndi 72% pogwiritsa ntchito kuyesa kwa post-32P. Chifukwa chake, kudyetsa 1% DBM zakudya ku mbewa za Sencar kudaletsa mapangidwe a DMBA-DNA omwe amatulutsa m'matumbo a mammary ndikuchepetsa kuchuluka kwa mammary gland mu vivo. Zotsatirazi zitha kufotokozera mphamvu zoletsa za DBM yazakudya pa mammary carcinogenesis mu mbewa.


Post nthawi: Aug-12-2020